Yong Chen Selected Research

Small Interfering RNA (siRNA)

1/2022	Systemically Silencing Long Non-coding RNAs Maclpil With Short Interfering RNA Nanoparticles Alleviates Experimental Ischemic Stroke by Promoting Macrophage Apoptosis and Anti-inflammatory Activation.
4/2020	Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly.
12/2019	Metabolism of Reactive Oxygen Species in Osteosarcoma and Potential Treatment Applications.
1/2019	LPS promote Osteosarcoma invasion and migration through TLR4/HOTAIR.
12/2017	Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo.
7/2017	Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells.
4/2017	Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway.
1/2017	miRNA-148a serves as a prognostic factor and suppresses migration and invasion through Wnt1 in non-small cell lung cancer.
1/2016	Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammation.
10/2015	Focal adhesion kinase overexpression and its impact on human osteosarcoma.

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Yong Chen Research Topics

Disease

255	Neoplasms (Cancer) 07/2022 - 06/2002
65	Inflammation (Inflammations) 12/2022 - 06/2002
50	Neoplasm Metastasis (Metastasis) 03/2022 - 10/2005
43	Pain (Aches) 01/2022 - 05/2002
38	Hepatocellular Carcinoma (Hepatoma) 07/2022 - 06/2002
38	Infections 02/2022 - 08/2003
33	Nasopharyngeal Carcinoma 03/2022 - 10/2005
32	Glioma (Gliomas) 01/2022 - 01/2013
28	Carcinoma (Carcinomatosis) 11/2021 - 11/2002
21	Lung Neoplasms (Lung Cancer) 05/2022 - 12/2005
20	Atherosclerosis 07/2022 - 02/2008
20	Insulin Resistance 01/2022 - 08/2003
19	Breast Neoplasms (Breast Cancer) 10/2022 - 02/2003
18	Fibrosis (Cirrhosis) 12/2022 - 04/2003
18	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 07/2013
17	Hypoxia (Hypoxemia) 05/2022 - 01/2008
16	Stomach Neoplasms (Stomach Cancer) 05/2022 - 10/2007
16	Melanoma (Melanoma, Malignant) 01/2022 - 01/2012
16	Osteosarcoma (Osteogenic Sarcoma) 09/2021 - 05/2012
15	Liver Neoplasms (Liver Cancer) 01/2022 - 08/2003
15	Hemorrhage 06/2021 - 07/2003
14	Necrosis 05/2022 - 10/2003
14	Reperfusion Injury 02/2022 - 01/2008
13	Lymphatic Metastasis 01/2022 - 09/2006
13	Type 2 Diabetes Mellitus (MODY) 01/2022 - 01/2010
13	Stroke (Strokes) 01/2022 - 12/2002
12	COVID-19 11/2022 - 01/2020
12	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2021 - 11/2002
12	Hyperalgesia 01/2021 - 11/2003
11	Carcinogenesis 07/2022 - 03/2003
11	Thrombosis (Thrombus) 01/2022 - 02/2014
11	Rheumatoid Arthritis 01/2021 - 04/2008
10	Sepsis (Septicemia) 10/2022 - 04/2003
10	Wounds and Injuries (Trauma) 02/2022 - 07/2003
10	Experimental Arthritis 01/2022 - 01/2016
10	Ischemic Stroke 01/2022 - 12/2002
10	Liver Diseases (Liver Disease) 01/2022 - 04/2003
10	Hypertension (High Blood Pressure) 01/2022 - 05/2010
10	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2016
10	Disease Progression 01/2021 - 06/2002
10	Brain Injuries (Brain Injury) 01/2019 - 12/2002
9	Body Weight (Weight, Body) 02/2022 - 06/2014
9	Obesity 12/2021 - 01/2016
9	Human Influenza (Influenza) 01/2021 - 05/2009
9	Chronic Hepatitis B 01/2021 - 05/2007
8	Osteoarthritis 03/2022 - 11/2014
8	Heart Failure 01/2022 - 03/2009
8	Infarction (Infarctions) 01/2022 - 12/2003

Drug/Important Bio-Agent (IBA)

95	Proteins (Proteins, Gene)FDA Link 05/2022 - 06/2002
61	Biomarkers (Surrogate Marker)IBA 12/2022 - 03/2009
54	Pharmaceutical PreparationsIBA 07/2022 - 06/2002
37	Messenger RNA (mRNA)IBA 03/2022 - 04/2005
35	CytokinesIBA 07/2022 - 06/2003
32	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2008
31	DNA (Deoxyribonucleic Acid)IBA 03/2022 - 05/2007
26	Glucose (Dextrose)FDA LinkGeneric 05/2022 - 08/2003
25	Therapeutic UsesIBA 07/2022 - 09/2004
24	LipidsIBA 01/2022 - 02/2008
21	Biological ProductsIBA 01/2022 - 11/2005
20	Long Noncoding RNAIBA 07/2022 - 04/2017
17	RNA (Ribonucleic Acid)IBA 01/2022 - 03/2003
15	Temozolomide (Temodar)FDA LinkGeneric 01/2022 - 10/2015
14	Small Interfering RNA (siRNA)IBA 01/2022 - 01/2008
14	VaccinesIBA 01/2022 - 08/2003
13	Indicators and Reagents (Reagents)IBA 12/2022 - 04/2011
13	Anti-Bacterial Agents (Antibiotics)IBA 02/2022 - 06/2005
13	C-Reactive ProteinIBA 06/2021 - 03/2007
12	Antiviral Agents (Antivirals)IBA 04/2021 - 05/2007
12	Freund's AdjuvantIBA 11/2018 - 11/2003
11	Cisplatin (Platino)FDA LinkGeneric 07/2022 - 12/2010
11	Peptides (Polypeptides)IBA 05/2022 - 08/2012
11	EnzymesIBA 01/2022 - 03/2010
10	Interleukin-6 (Interleukin 6)IBA 07/2022 - 04/2012
10	AntigensIBA 01/2022 - 08/2003
10	CholesterolIBA 07/2021 - 02/2008
9	Analgesics (Analgesic Drugs)IBA 11/2022 - 05/2008
9	oxidized low density lipoproteinIBA 07/2022 - 03/2013
9	Transcription Factors (Transcription Factor)IBA 05/2022 - 04/2008
9	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2022 - 07/2013
9	Phosphotransferases (Kinase)IBA 01/2022 - 08/2010
9	Triglycerides (Triacylglycerol)IBA 01/2022 - 08/2011
9	CyclodextrinsIBA 03/2021 - 04/2012
8	MethyltransferasesIBA 06/2022 - 01/2013
8	LigandsIBA 03/2022 - 01/2013
8	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2022 - 02/2003
8	Protein Isoforms (Isoforms)IBA 01/2022 - 10/2007
8	AlbuminsIBA 08/2021 - 01/2014
8	Insulin (Novolin)FDA Link 08/2021 - 08/2003

Therapy/Procedure

118	Therapeutics 03/2022 - 06/2002
51	Drug Therapy (Chemotherapy) 07/2022 - 08/2008
37	Radiotherapy 06/2022 - 10/2005
16	Transplantation 05/2021 - 09/2003
15	Lymph Node Excision (Lymph Node Dissection) 11/2020 - 11/2002
12	Hysterectomy 01/2021 - 11/2002
10	Length of Stay 10/2022 - 03/2013
10	Neoadjuvant Therapy 02/2022 - 05/2012
10	Chinese Traditional Medicine (Traditional Chinese Medicine) 02/2022 - 05/2015
10	Immunotherapy 01/2022 - 02/2015
9	Chemoradiotherapy 05/2022 - 08/2008
8	Aftercare (After-Treatment) 11/2022 - 04/2008